Serum Insulin-Like Growth Factor-I Is Positively Associated with Serum Prostate-Specific Antigen in Middle-Aged Men without Evidence of Prostate Cancer

Steven E. Oliver; Barney Barrass; David J. Gunnell; Jenny L. Donovan; Tim J. Peters; Raj A. Persad; David Gillatt; David E. Neal; Freddie C. Hamdy; Jeff M.P. Holly

doi:10.1158/1055-9965.EPI-03-0102

Serum Insulin-Like Growth Factor-I Is Positively Associated with Serum Prostate-Specific Antigen in Middle-Aged Men without Evidence of Prostate Cancer

Steven E. Oliver, Barney Barrass, David J. Gunnell, Jenny L. Donovan, Tim J. Peters, Raj A. Persad, David Gillatt, David E. Neal, Freddie C. Hamdy, Jeff M.P. Holly

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17 Scopus citations

Abstract

We have examined the relationship between serum insulin-like growth factor-I (IGF-I) and prostate-specific antigen in 367 healthy men without evidence of prostate cancer and found a positive association (P = 0.05). In men without prostate cancer, serum prostate-specific antigen is closely related to prostate size, and our findings, therefore, suggest that IGF-I may induce prostatic epithelial proliferation. Higher circulating levels of IGF-I have been associated with increased risk of both prostate cancer and possibly benign prostatic hyperplasia. Greater rates of cell proliferation induced by IGF-I may be a key biological pathway underlying these disorders.

Original language	English
Pages (from-to)	163-165
Number of pages	3
Journal	Cancer Epidemiology Biomarkers and Prevention
Volume	13
Issue number	1
DOIs	https://doi.org/10.1158/1055-9965.EPI-03-0102
State	Published - Jan 2004
Externally published	Yes

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Oliver, S. E., Barrass, B., Gunnell, D. J., Donovan, J. L., Peters, T. J., Persad, R. A., Gillatt, D., Neal, D. E., Hamdy, F. C., & Holly, J. M. P. (2004). Serum Insulin-Like Growth Factor-I Is Positively Associated with Serum Prostate-Specific Antigen in Middle-Aged Men without Evidence of Prostate Cancer. Cancer Epidemiology Biomarkers and Prevention, 13(1), 163-165. https://doi.org/10.1158/1055-9965.EPI-03-0102

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title = "Serum Insulin-Like Growth Factor-I Is Positively Associated with Serum Prostate-Specific Antigen in Middle-Aged Men without Evidence of Prostate Cancer",

abstract = "We have examined the relationship between serum insulin-like growth factor-I (IGF-I) and prostate-specific antigen in 367 healthy men without evidence of prostate cancer and found a positive association (P = 0.05). In men without prostate cancer, serum prostate-specific antigen is closely related to prostate size, and our findings, therefore, suggest that IGF-I may induce prostatic epithelial proliferation. Higher circulating levels of IGF-I have been associated with increased risk of both prostate cancer and possibly benign prostatic hyperplasia. Greater rates of cell proliferation induced by IGF-I may be a key biological pathway underlying these disorders.",

author = "Oliver, {Steven E.} and Barney Barrass and Gunnell, {David J.} and Donovan, {Jenny L.} and Peters, {Tim J.} and Persad, {Raj A.} and David Gillatt and Neal, {David E.} and Hamdy, {Freddie C.} and Holly, {Jeff M.P.}",

year = "2004",

month = jan,

doi = "10.1158/1055-9965.EPI-03-0102",

language = "Ingl{\'e}s",

volume = "13",

pages = "163--165",

journal = "Cancer Epidemiology Biomarkers and Prevention",

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Oliver, SE, Barrass, B, Gunnell, DJ, Donovan, JL, Peters, TJ, Persad, RA, Gillatt, D, Neal, DE, Hamdy, FC & Holly, JMP 2004, 'Serum Insulin-Like Growth Factor-I Is Positively Associated with Serum Prostate-Specific Antigen in Middle-Aged Men without Evidence of Prostate Cancer', Cancer Epidemiology Biomarkers and Prevention, vol. 13, no. 1, pp. 163-165. https://doi.org/10.1158/1055-9965.EPI-03-0102

Serum Insulin-Like Growth Factor-I Is Positively Associated with Serum Prostate-Specific Antigen in Middle-Aged Men without Evidence of Prostate Cancer. / Oliver, Steven E.; Barrass, Barney; Gunnell, David J. et al.
In: Cancer Epidemiology Biomarkers and Prevention, Vol. 13, No. 1, 01.2004, p. 163-165.

Research output: Contribution to journal › Article › peer-review

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T1 - Serum Insulin-Like Growth Factor-I Is Positively Associated with Serum Prostate-Specific Antigen in Middle-Aged Men without Evidence of Prostate Cancer

AU - Oliver, Steven E.

AU - Barrass, Barney

AU - Gunnell, David J.

AU - Donovan, Jenny L.

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AU - Persad, Raj A.

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AU - Hamdy, Freddie C.

AU - Holly, Jeff M.P.

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N2 - We have examined the relationship between serum insulin-like growth factor-I (IGF-I) and prostate-specific antigen in 367 healthy men without evidence of prostate cancer and found a positive association (P = 0.05). In men without prostate cancer, serum prostate-specific antigen is closely related to prostate size, and our findings, therefore, suggest that IGF-I may induce prostatic epithelial proliferation. Higher circulating levels of IGF-I have been associated with increased risk of both prostate cancer and possibly benign prostatic hyperplasia. Greater rates of cell proliferation induced by IGF-I may be a key biological pathway underlying these disorders.

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Serum Insulin-Like Growth Factor-I Is Positively Associated with Serum Prostate-Specific Antigen in Middle-Aged Men without Evidence of Prostate Cancer

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