Reevaluating safety pharmacology respiratory studies within the ICH S7A core battery: A multi-company evaluation of preclinical utility and clinical translation

Keyphrases

• Safety Pharmacology 100%
• Core Battery 100%
• ICH S7A 100%
• Company Evaluation 100%
• Clinical Translation 100%
• First-in-human 100%
• Multi-company 100%
• Pharmacology Studies 50%
• Clinical Adverse Events 50%
• Clinical Trials 50%
• Regulatory Submission 50%
• Drug Development 50%
• Drug Candidates 50%
• Clinically Significant 50%
• Incidence Rate 50%
• Prognostic Value 50%
• Pharmaceutical Companies 50%
• Dyspnea 50%
• Contingency Table 50%
• Cough 50%
• Adverse Event Reporting 50%
• Novel Molecules 50%
• Preclinical Assays 50%
• Guideline Review 50%
• Large Database 50%
• Safety Guidelines 50%
• Resource Conservation 50%
• Pharmaceutical Molecules 50%
• Respiratory Adverse Events 50%
• Overall Incidence 50%
• Conservation Animals 50%
• Extensive Analysis 50%
• Animal Reduction 50%

Pharmacology, Toxicology and Pharmaceutical Science

• Safety Pharmacology 100%
• Adverse Event 100%
• Human Study 50%
• Drug Development 50%
• Clinical Trial 50%
• Dyspnea 50%
• Coughing 50%