Monoclonality of Multiple Bladder Cancers

R. T.D. Oliver; David N. Feldman; David Sidransky; Bert Vogelstein; Philip Frost; Andrew C. Von Eschenbach; D. E. Neal; A. L. Harris

doi:10.1056/NEJM199208063270616

Monoclonality of Multiple Bladder Cancers

R. T.D. Oliver, David N. Feldman, David Sidransky, Bert Vogelstein, Philip Frost, Andrew C. Von Eschenbach, D. E. Neal, A. L. Harris

Research output: Contribution to journal › Letter › peer-review

Abstract

To the Editor: In reference to the report of Sidransky et al. (March 12 issue)¹, I would accept the view that the most likely explanation of their findings is monoclonality of the multiple tumors tested. However, the limited clinical histories provided do not allow one to exclude the possibility that the tumors arose from implantation after an earlier transurethral resection. This has been clearly demonstrated to occur in carefully controlled studies of the effect of chemical cystitis and electrocautery in laboratory animals² ^, ³ and was not considered in the authors' discussion or that of the accompanying editorial.⁴ Such an explanation…

Original language	English
Pages (from-to)	433-435
Number of pages	3
Journal	New England Journal of Medicine
Volume	327
Issue number	6
DOIs	https://doi.org/10.1056/NEJM199208063270616
State	Published - Aug 6 1992
Externally published	Yes

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title = "Monoclonality of Multiple Bladder Cancers",

abstract = "To the Editor: In reference to the report of Sidransky et al. (March 12 issue)1, I would accept the view that the most likely explanation of their findings is monoclonality of the multiple tumors tested. However, the limited clinical histories provided do not allow one to exclude the possibility that the tumors arose from implantation after an earlier transurethral resection. This has been clearly demonstrated to occur in carefully controlled studies of the effect of chemical cystitis and electrocautery in laboratory animals2 , 3 and was not considered in the authors' discussion or that of the accompanying editorial.4 Such an explanation…",

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AU - Oliver, R. T.D.

AU - Feldman, David N.

AU - Sidransky, David

AU - Vogelstein, Bert

AU - Frost, Philip

AU - Von Eschenbach, Andrew C.

AU - Neal, D. E.

AU - Harris, A. L.

PY - 1992/8/6

Y1 - 1992/8/6

N2 - To the Editor: In reference to the report of Sidransky et al. (March 12 issue)1, I would accept the view that the most likely explanation of their findings is monoclonality of the multiple tumors tested. However, the limited clinical histories provided do not allow one to exclude the possibility that the tumors arose from implantation after an earlier transurethral resection. This has been clearly demonstrated to occur in carefully controlled studies of the effect of chemical cystitis and electrocautery in laboratory animals2 , 3 and was not considered in the authors' discussion or that of the accompanying editorial.4 Such an explanation…

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ER -

Monoclonality of Multiple Bladder Cancers

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