Mechanism of synergistic carcinogenesis from hypergastrinemia and helicobacter infection

Anton Yuryev

doi:10.2174/978160805437411201010131

Mechanism of synergistic carcinogenesis from hypergastrinemia and helicobacter infection

Research output: Chapter in Book/Report/Conference proceeding › Chapter › peer-review

Abstract

We have built a model for gastric cancer predisposition caused by hypergastrenimia during Helicobacter infection. The model was built using publically available data form hypergastrenimic transgenic mice infected with Helicobacter. We used the model to identify potential drug targets for gastric cancer, annexin II and TRAF6, and to find prognostic biomarkers for gastric cancer predisposition due to hypergastrenimia.

Original language	English
Title of host publication	From Knowledge Networks to Biological Models
Publisher	Bentham Science Publishers Ltd.
Pages	131-150
Number of pages	20
ISBN (Print)	9781608054367
DOIs	https://doi.org/10.2174/978160805437411201010131
State	Published - 2012
Externally published	Yes

Keywords

Annexin
Bioinformatics
Biomarkers
Gastric cancer
Gastrin
Gene expression microarray
Helicobacter
Mechanistic model
NF-KappaB
Pathway analysis
Pathway studio
Stomach cancer
Subnetwork enrichment analysis

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10.2174/978160805437411201010131

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KW - Annexin

KW - Bioinformatics

KW - Biomarkers

KW - Gastric cancer

KW - Gastrin

KW - Gene expression microarray

KW - Helicobacter

KW - Mechanistic model

KW - NF-KappaB

KW - Pathway analysis

KW - Pathway studio

KW - Stomach cancer

KW - Subnetwork enrichment analysis

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BT - From Knowledge Networks to Biological Models

PB - Bentham Science Publishers Ltd.

ER -

Mechanism of synergistic carcinogenesis from hypergastrinemia and helicobacter infection

Abstract

Keywords

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