Kinase joins the chaperone club: Androgen-regulated kinome reveals choline kinase alpha as a potential drug target in prostate cancer

Mohammad Asim; Charlie E. Massie; David E. Neal

doi:10.1080/23723556.2016.1140262

Kinase joins the chaperone club: Androgen-regulated kinome reveals choline kinase alpha as a potential drug target in prostate cancer

Mohammad Asim, Charlie E. Massie, David E. Neal

Research output: Contribution to journal › Article › peer-review

6 Scopus citations

Abstract

To identify clinically relevant downstream effectors of androgen signaling, the androgen-regulated kinome was defined in prostate cancer (PCa). Within this study, choline kinase α (CHKA) was identified as an androgen receptor chaperone that is both a biomarker of progression and a potential therapeutic target for PCa.

Original language	English
Article number	e1140262
Journal	Molecular and Cellular Oncology
Volume	3
Issue number	3
DOIs	https://doi.org/10.1080/23723556.2016.1140262
State	Published - May 3 2016
Externally published	Yes

Keywords

Androgen Receptor
chaperones
prostate cancer
therapeutic target

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10.1080/23723556.2016.1140262

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title = "Kinase joins the chaperone club: Androgen-regulated kinome reveals choline kinase alpha as a potential drug target in prostate cancer",

abstract = "To identify clinically relevant downstream effectors of androgen signaling, the androgen-regulated kinome was defined in prostate cancer (PCa). Within this study, choline kinase α (CHKA) was identified as an androgen receptor chaperone that is both a biomarker of progression and a potential therapeutic target for PCa.",

keywords = "Androgen Receptor, chaperones, prostate cancer, therapeutic target",

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AU - Massie, Charlie E.

AU - Neal, David E.

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AB - To identify clinically relevant downstream effectors of androgen signaling, the androgen-regulated kinome was defined in prostate cancer (PCa). Within this study, choline kinase α (CHKA) was identified as an androgen receptor chaperone that is both a biomarker of progression and a potential therapeutic target for PCa.

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KW - therapeutic target

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Kinase joins the chaperone club: Androgen-regulated kinome reveals choline kinase alpha as a potential drug target in prostate cancer

Abstract

Keywords

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