Keyphrases
Crystallization
100%
CYP46A1
100%
Fluvoxamine
100%
In Silico
100%
Marketed Drugs
100%
Active Sites
37%
Access Channel
25%
Substrate Access
25%
Binder
25%
Cytochrome P450 (CYP450)
12%
Cholesterol
12%
Cholesterol 24-hydroxylase
12%
Drug Binding
12%
Spectral Binding
12%
Amino Acid Residues
12%
Aliphatic Amino Acids
12%
Enzyme Binding
12%
Therapeutic Agents
12%
Spectral Response
12%
Heme Iron
12%
Binding Assay
12%
Heme Group
12%
Tight
12%
Phenyl Ring
12%
Pharmaceutical Agents
12%
Hydroxylation
12%
Kd Values
12%
Antidepressants
12%
Protein Side Chains
12%
Hydrophobic Interaction
12%
Brain Enzymes
12%
Methoxy
12%
Y-shaped
12%
Aromatic Side Chains
12%
U.S. Food
12%
P450 Substrates
12%
Chemistry
Fluvoxamine
100%
% Inhibition
100%
Heme
66%
Conformational Isomer
66%
Cytochrome P450
33%
Kd
33%
Crystal Structure
33%
Antidepressant
33%
Hydroxylation
33%
Amino-Acid Residue
33%
Biochemistry, Genetics and Molecular Biology
Fluvoxamine
100%
CYP46A1
100%
Computer Model
100%
Enzyme
100%
Active Site
37%
Drug Binding
12%
Cytochrome P450
12%
Oxygenase
12%
Amino Acids
12%
Crystal Structure
12%
Hydroxylation
12%
Pharmacology, Toxicology and Pharmaceutical Science
Fluvoxamine
100%
Crystallization
100%
Cholesterol 24 Hydroxylase
66%
Heme
66%
Brain Enzyme
33%
Antidepressant
33%
Cytochrome P450
33%
Amino Acid
33%