TY - GEN
T1 - Identifying local gene expression patterns in biomolecular networks
AU - Sivachenko, A. Y.
AU - Yuryev, A.
AU - Daraselia, N.
AU - Mazo, I.
PY - 2005
Y1 - 2005
N2 - This study is aimed at elucidating putative transcription regulators TRs responsible for the observed differential expression pattern. Combined direct promoter binding and indirect transcriptional regulation networks were used, and the expression levels of each TR's downstream targets were collectively analyzed, as a sample, for significance. Statistical procedure was also developed that takes into account the sign of the expression change, thus requiring the downstream targets to exhibit expression pattern consistent with the regulatory relationship effect signs.
AB - This study is aimed at elucidating putative transcription regulators TRs responsible for the observed differential expression pattern. Combined direct promoter binding and indirect transcriptional regulation networks were used, and the expression levels of each TR's downstream targets were collectively analyzed, as a sample, for significance. Statistical procedure was also developed that takes into account the sign of the expression change, thus requiring the downstream targets to exhibit expression pattern consistent with the regulatory relationship effect signs.
UR - http://www.scopus.com/inward/record.url?scp=33749052291&partnerID=8YFLogxK
U2 - 10.1109/CSBW.2005.72
DO - 10.1109/CSBW.2005.72
M3 - Contribución a la conferencia
AN - SCOPUS:33749052291
SN - 0769524427
SN - 9780769524429
T3 - 2005 IEEE Computational Systems Bioinformatics Conference, Workshops and Poster Abstracts
SP - 180
EP - 181
BT - 2005 IEEE Computational Systems Bioinformatics Conference, Workshops and Poster Abstracts
T2 - 2005 IEEE Computational Systems Bioinformatics Conference, Workshops and Poster Abstracts
Y2 - 8 August 2005 through 11 August 2005
ER -