Identifying local gene expression patterns in biomolecular networks

A. Y. Sivachenko, A. Yuryev, N. Daraselia, I. Mazo

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

9 Scopus citations

Abstract

This study is aimed at elucidating putative transcription regulators TRs responsible for the observed differential expression pattern. Combined direct promoter binding and indirect transcriptional regulation networks were used, and the expression levels of each TR's downstream targets were collectively analyzed, as a sample, for significance. Statistical procedure was also developed that takes into account the sign of the expression change, thus requiring the downstream targets to exhibit expression pattern consistent with the regulatory relationship effect signs.

Original languageEnglish
Title of host publication2005 IEEE Computational Systems Bioinformatics Conference, Workshops and Poster Abstracts
Pages180-181
Number of pages2
DOIs
StatePublished - 2005
Externally publishedYes
Event2005 IEEE Computational Systems Bioinformatics Conference, Workshops and Poster Abstracts - Stanford, CA, United States
Duration: Aug 8 2005Aug 11 2005

Publication series

Name2005 IEEE Computational Systems Bioinformatics Conference, Workshops and Poster Abstracts

Conference

Conference2005 IEEE Computational Systems Bioinformatics Conference, Workshops and Poster Abstracts
Country/TerritoryUnited States
CityStanford, CA
Period08/8/0508/11/05

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