Identification of new genetic risk factors for prostate cancer

Michelle Guy; Zsofia Kote-Jarai; Graham G. Giles; Ali Amin Al Olama; Sarah K. Jugurnauth; Shani Mulholland; Daniel A. Leongamornlert; Stephen M. Edwards; Jonathan Morrison; Helen I. Field; Melissa C. Southey; Gianluca Severi; Jenny L. Donovan; Freddie C. Hamdy; David P. Dearnaley; Kenneth R. Muir; Charmaine Smith; Melisa Bagnato; Audrey T. Ardern-Jones; Amanda L. Hall; Lynne T. O'Brien; Beatrice N. Gehr-Swain; Rosemary A. Wilkinson; Angela Cox; Sarah Lewis; Paul M. Brown; Sameer G. Jhavar; Malgorzata Tymrakiewicz; Artitaya Lophatananon; Sarah L. Bryant; Alan Horwich; Robert A. Huddart; Vincent S. Khoo; Christopher C. Parker; Christopher J. Woodhouse; Alan Thompson; Tim Christmas; Chris Ogden; Cyril Fisher; Charles Jameson; Colin S. Cooper; Dallas R. English; John L. Hopper; David E. Neal; Douglas F. Easton; Rosalind A. Eeles

doi:10.1038/aja.2008.18

Identification of new genetic risk factors for prostate cancer

Michelle Guy, Zsofia Kote-Jarai, Graham G. Giles, Ali Amin Al Olama, Sarah K. Jugurnauth, Shani Mulholland, Daniel A. Leongamornlert, Stephen M. Edwards, Jonathan Morrison, Helen I. Field, Melissa C. Southey, Gianluca Severi, Jenny L. Donovan, Freddie C. Hamdy, David P. Dearnaley, Kenneth R. Muir, Charmaine Smith, Melisa Bagnato, Audrey T. Ardern-Jones, Amanda L. HallLynne T. O'Brien, Beatrice N. Gehr-Swain, Rosemary A. Wilkinson, Angela Cox, Sarah Lewis, Paul M. Brown, Sameer G. Jhavar, Malgorzata Tymrakiewicz, Artitaya Lophatananon, Sarah L. Bryant, Alan Horwich, Robert A. Huddart, Vincent S. Khoo, Christopher C. Parker, Christopher J. Woodhouse, Alan Thompson, Tim Christmas, Chris Ogden, Cyril Fisher, Charles Jameson, Colin S. Cooper, Dallas R. English, John L. Hopper, David E. Neal, Douglas F. Easton, Rosalind A. Eeles

Research output: Contribution to journal › Review article › peer-review

19 Scopus citations

Abstract

There is evidence that a substantial part of genetic predisposition to prostate cancer (PCa) may be due to lower penetrance genes which are found by genome-wide association studies. We have recently conducted such a study and seven new regions of the genome linked to PCa risk have been identified. Three of these loci contain candidate susceptibility genes: MSMB, LMTK2 and KLK2/3. The MSMB and KLK2/3 genes may be useful for PCa screening, and the LMTK2 gene might provide a potential therapeutic target. Together with results from other groups, there are now 23 germline genetic variants which have been reported. These results have the potential to be developed into a genetic test. However, we consider that marketing of tests to the public is premature, as PCa risk can not be evaluated fully at this stage and the appropriate screening protocols need to be developed. Follow-up validation studies, as well as studies to explore the psychological implications of genetic profile testing, will be vital prior to roll out into healthcare.

Original language	English
Pages (from-to)	49-55
Number of pages	7
Journal	Asian Journal of Andrology
Volume	11
Issue number	1
DOIs	https://doi.org/10.1038/aja.2008.18
State	Published - 2009
Externally published	Yes

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Guy, M., Kote-Jarai, Z., Giles, G. G., Al Olama, A. A., Jugurnauth, S. K., Mulholland, S., Leongamornlert, D. A., Edwards, S. M., Morrison, J., Field, H. I., Southey, M. C., Severi, G., Donovan, J. L., Hamdy, F. C., Dearnaley, D. P., Muir, K. R., Smith, C., Bagnato, M., Ardern-Jones, A. T., ... Eeles, R. A. (2009). Identification of new genetic risk factors for prostate cancer. Asian Journal of Andrology, 11(1), 49-55. https://doi.org/10.1038/aja.2008.18

@article{ed48d4d58a564c2799f07b4479197c11,

title = "Identification of new genetic risk factors for prostate cancer",

abstract = "There is evidence that a substantial part of genetic predisposition to prostate cancer (PCa) may be due to lower penetrance genes which are found by genome-wide association studies. We have recently conducted such a study and seven new regions of the genome linked to PCa risk have been identified. Three of these loci contain candidate susceptibility genes: MSMB, LMTK2 and KLK2/3. The MSMB and KLK2/3 genes may be useful for PCa screening, and the LMTK2 gene might provide a potential therapeutic target. Together with results from other groups, there are now 23 germline genetic variants which have been reported. These results have the potential to be developed into a genetic test. However, we consider that marketing of tests to the public is premature, as PCa risk can not be evaluated fully at this stage and the appropriate screening protocols need to be developed. Follow-up validation studies, as well as studies to explore the psychological implications of genetic profile testing, will be vital prior to roll out into healthcare.",

author = "Michelle Guy and Zsofia Kote-Jarai and Giles, {Graham G.} and {Al Olama}, {Ali Amin} and Jugurnauth, {Sarah K.} and Shani Mulholland and Leongamornlert, {Daniel A.} and Edwards, {Stephen M.} and Jonathan Morrison and Field, {Helen I.} and Southey, {Melissa C.} and Gianluca Severi and Donovan, {Jenny L.} and Hamdy, {Freddie C.} and Dearnaley, {David P.} and Muir, {Kenneth R.} and Charmaine Smith and Melisa Bagnato and Ardern-Jones, {Audrey T.} and Hall, {Amanda L.} and O'Brien, {Lynne T.} and Gehr-Swain, {Beatrice N.} and Wilkinson, {Rosemary A.} and Angela Cox and Sarah Lewis and Brown, {Paul M.} and Jhavar, {Sameer G.} and Malgorzata Tymrakiewicz and Artitaya Lophatananon and Bryant, {Sarah L.} and Alan Horwich and Huddart, {Robert A.} and Khoo, {Vincent S.} and Parker, {Christopher C.} and Woodhouse, {Christopher J.} and Alan Thompson and Tim Christmas and Chris Ogden and Cyril Fisher and Charles Jameson and Cooper, {Colin S.} and English, {Dallas R.} and Hopper, {John L.} and Neal, {David E.} and Easton, {Douglas F.} and Eeles, {Rosalind A.}",

year = "2009",

doi = "10.1038/aja.2008.18",

language = "Ingl{\'e}s",

volume = "11",

pages = "49--55",

journal = "Asian Journal of Andrology",

issn = "1008-682X",

publisher = "Wolters Kluwer Medknow Publications",

number = "1",

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Guy, M, Kote-Jarai, Z, Giles, GG, Al Olama, AA, Jugurnauth, SK, Mulholland, S, Leongamornlert, DA, Edwards, SM, Morrison, J, Field, HI, Southey, MC, Severi, G, Donovan, JL, Hamdy, FC, Dearnaley, DP, Muir, KR, Smith, C, Bagnato, M, Ardern-Jones, AT, Hall, AL, O'Brien, LT, Gehr-Swain, BN, Wilkinson, RA, Cox, A, Lewis, S, Brown, PM, Jhavar, SG, Tymrakiewicz, M, Lophatananon, A, Bryant, SL, Horwich, A, Huddart, RA, Khoo, VS, Parker, CC, Woodhouse, CJ, Thompson, A, Christmas, T, Ogden, C, Fisher, C, Jameson, C, Cooper, CS, English, DR, Hopper, JL, Neal, DE, Easton, DF & Eeles, RA 2009, 'Identification of new genetic risk factors for prostate cancer', Asian Journal of Andrology, vol. 11, no. 1, pp. 49-55. https://doi.org/10.1038/aja.2008.18

TY - JOUR

T1 - Identification of new genetic risk factors for prostate cancer

AU - Guy, Michelle

AU - Kote-Jarai, Zsofia

AU - Giles, Graham G.

AU - Al Olama, Ali Amin

AU - Jugurnauth, Sarah K.

AU - Mulholland, Shani

AU - Leongamornlert, Daniel A.

AU - Edwards, Stephen M.

AU - Morrison, Jonathan

AU - Field, Helen I.

AU - Southey, Melissa C.

AU - Severi, Gianluca

AU - Donovan, Jenny L.

AU - Hamdy, Freddie C.

AU - Dearnaley, David P.

AU - Muir, Kenneth R.

AU - Smith, Charmaine

AU - Bagnato, Melisa

AU - Ardern-Jones, Audrey T.

AU - Hall, Amanda L.

AU - O'Brien, Lynne T.

AU - Gehr-Swain, Beatrice N.

AU - Wilkinson, Rosemary A.

AU - Cox, Angela

AU - Lewis, Sarah

AU - Brown, Paul M.

AU - Jhavar, Sameer G.

AU - Tymrakiewicz, Malgorzata

AU - Lophatananon, Artitaya

AU - Bryant, Sarah L.

AU - Horwich, Alan

AU - Huddart, Robert A.

AU - Khoo, Vincent S.

AU - Parker, Christopher C.

AU - Woodhouse, Christopher J.

AU - Thompson, Alan

AU - Christmas, Tim

AU - Ogden, Chris

AU - Fisher, Cyril

AU - Jameson, Charles

AU - Cooper, Colin S.

AU - English, Dallas R.

AU - Hopper, John L.

AU - Neal, David E.

AU - Easton, Douglas F.

AU - Eeles, Rosalind A.

PY - 2009

Y1 - 2009

N2 - There is evidence that a substantial part of genetic predisposition to prostate cancer (PCa) may be due to lower penetrance genes which are found by genome-wide association studies. We have recently conducted such a study and seven new regions of the genome linked to PCa risk have been identified. Three of these loci contain candidate susceptibility genes: MSMB, LMTK2 and KLK2/3. The MSMB and KLK2/3 genes may be useful for PCa screening, and the LMTK2 gene might provide a potential therapeutic target. Together with results from other groups, there are now 23 germline genetic variants which have been reported. These results have the potential to be developed into a genetic test. However, we consider that marketing of tests to the public is premature, as PCa risk can not be evaluated fully at this stage and the appropriate screening protocols need to be developed. Follow-up validation studies, as well as studies to explore the psychological implications of genetic profile testing, will be vital prior to roll out into healthcare.

AB - There is evidence that a substantial part of genetic predisposition to prostate cancer (PCa) may be due to lower penetrance genes which are found by genome-wide association studies. We have recently conducted such a study and seven new regions of the genome linked to PCa risk have been identified. Three of these loci contain candidate susceptibility genes: MSMB, LMTK2 and KLK2/3. The MSMB and KLK2/3 genes may be useful for PCa screening, and the LMTK2 gene might provide a potential therapeutic target. Together with results from other groups, there are now 23 germline genetic variants which have been reported. These results have the potential to be developed into a genetic test. However, we consider that marketing of tests to the public is premature, as PCa risk can not be evaluated fully at this stage and the appropriate screening protocols need to be developed. Follow-up validation studies, as well as studies to explore the psychological implications of genetic profile testing, will be vital prior to roll out into healthcare.

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U2 - 10.1038/aja.2008.18

DO - 10.1038/aja.2008.18

M3 - Artículo de revisión

C2 - 19050691

AN - SCOPUS:69449103575

SN - 1008-682X

VL - 11

SP - 49

EP - 55

JO - Asian Journal of Andrology

JF - Asian Journal of Andrology

IS - 1

ER -

Identification of new genetic risk factors for prostate cancer

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