Epidermal-growth-factor receptors in human bladder cancer: Comparison of invasive and superficial tumours

David E. Neal; Reginald R. Hall; Colin Marsh; Paul D. Abel; J. R.C. Sainsbury; Adrian L. Harris

doi:10.1016/S0140-6736(85)91386-8

Epidermal-growth-factor receptors in human bladder cancer: Comparison of invasive and superficial tumours

David E. Neal, Reginald R. Hall, Colin Marsh, Paul D. Abel, J. R.C. Sainsbury, Adrian L. Harris

Research output: Contribution to journal › Article › peer-review

568 Scopus citations

Abstract

The presence of epidermal-growth-factor (EGF) receptors in normal and neoplastic human urothelium was studied in 12 control patients and in 48 patients with transitional cell carcinoma of the bladder, 24 with invasive (pT3) and 24 with superficial tumours (9 pT1, 15 pTa). EGF receptors were identified on frozen sections by means of an indirect immunoperoxidase technique with a monoclonal antibody against the EGF receptor. Significantly more invasive tumours (21 of 24) than superficial (7 of 24) were stained positively for the EGF receptor (χ²=14·49; p<0·001). Significantly more poorly differentiated tumours (18 of 21) than moderately differentiated tumours (10 of 27) were EGF-receptor positive (χ²=9·6; p<0·01). No control sample stained positively for the EGF receptor. These findings suggest that the presence of a high intensity of staining for the EGF receptor in human bladder tumours is associated with poor differentiation and with invasion.

Original language	English
Pages (from-to)	366-368
Number of pages	3
Journal	The Lancet
Volume	325
Issue number	8425
DOIs	https://doi.org/10.1016/S0140-6736(85)91386-8
State	Published - Feb 16 1985
Externally published	Yes

Access to Document

10.1016/S0140-6736(85)91386-8

Cite this

@article{12070ad6f6ff4c2993a3f172912fe2a6,

title = "Epidermal-growth-factor receptors in human bladder cancer: Comparison of invasive and superficial tumours",

abstract = "The presence of epidermal-growth-factor (EGF) receptors in normal and neoplastic human urothelium was studied in 12 control patients and in 48 patients with transitional cell carcinoma of the bladder, 24 with invasive (pT3) and 24 with superficial tumours (9 pT1, 15 pTa). EGF receptors were identified on frozen sections by means of an indirect immunoperoxidase technique with a monoclonal antibody against the EGF receptor. Significantly more invasive tumours (21 of 24) than superficial (7 of 24) were stained positively for the EGF receptor (χ2=14·49; p<0·001). Significantly more poorly differentiated tumours (18 of 21) than moderately differentiated tumours (10 of 27) were EGF-receptor positive (χ2=9·6; p<0·01). No control sample stained positively for the EGF receptor. These findings suggest that the presence of a high intensity of staining for the EGF receptor in human bladder tumours is associated with poor differentiation and with invasion.",

author = "Neal, {David E.} and Hall, {Reginald R.} and Colin Marsh and Abel, {Paul D.} and Sainsbury, {J. R.C.} and Harris, {Adrian L.}",

year = "1985",

month = feb,

day = "16",

doi = "10.1016/S0140-6736(85)91386-8",

language = "Ingl{\'e}s",

volume = "325",

pages = "366--368",

journal = "The Lancet",

issn = "0140-6736",

publisher = "Elsevier Ltd",

number = "8425",

}

TY - JOUR

T1 - Epidermal-growth-factor receptors in human bladder cancer

T2 - Comparison of invasive and superficial tumours

AU - Neal, David E.

AU - Hall, Reginald R.

AU - Marsh, Colin

AU - Abel, Paul D.

AU - Sainsbury, J. R.C.

AU - Harris, Adrian L.

PY - 1985/2/16

Y1 - 1985/2/16

N2 - The presence of epidermal-growth-factor (EGF) receptors in normal and neoplastic human urothelium was studied in 12 control patients and in 48 patients with transitional cell carcinoma of the bladder, 24 with invasive (pT3) and 24 with superficial tumours (9 pT1, 15 pTa). EGF receptors were identified on frozen sections by means of an indirect immunoperoxidase technique with a monoclonal antibody against the EGF receptor. Significantly more invasive tumours (21 of 24) than superficial (7 of 24) were stained positively for the EGF receptor (χ2=14·49; p<0·001). Significantly more poorly differentiated tumours (18 of 21) than moderately differentiated tumours (10 of 27) were EGF-receptor positive (χ2=9·6; p<0·01). No control sample stained positively for the EGF receptor. These findings suggest that the presence of a high intensity of staining for the EGF receptor in human bladder tumours is associated with poor differentiation and with invasion.

AB - The presence of epidermal-growth-factor (EGF) receptors in normal and neoplastic human urothelium was studied in 12 control patients and in 48 patients with transitional cell carcinoma of the bladder, 24 with invasive (pT3) and 24 with superficial tumours (9 pT1, 15 pTa). EGF receptors were identified on frozen sections by means of an indirect immunoperoxidase technique with a monoclonal antibody against the EGF receptor. Significantly more invasive tumours (21 of 24) than superficial (7 of 24) were stained positively for the EGF receptor (χ2=14·49; p<0·001). Significantly more poorly differentiated tumours (18 of 21) than moderately differentiated tumours (10 of 27) were EGF-receptor positive (χ2=9·6; p<0·01). No control sample stained positively for the EGF receptor. These findings suggest that the presence of a high intensity of staining for the EGF receptor in human bladder tumours is associated with poor differentiation and with invasion.

UR - http://www.scopus.com/inward/record.url?scp=84920241849&partnerID=8YFLogxK

U2 - 10.1016/S0140-6736(85)91386-8

DO - 10.1016/S0140-6736(85)91386-8

M3 - Artículo

C2 - 2857420

AN - SCOPUS:84920241849

SN - 0140-6736

VL - 325

SP - 366

EP - 368

JO - The Lancet

JF - The Lancet

IS - 8425

ER -

Epidermal-growth-factor receptors in human bladder cancer: Comparison of invasive and superficial tumours

Abstract

Access to Document

Other files and links

Fingerprint

Cite this