Abstract
Recently, expectations have been raised that molecular biological studies of human tumours may be of value in helping to predict future clinical behaviour. in terms of therapeutic response and long-term survival. The epidermal growth factor receptor (EGFr) is a cell surface receptor for EGF and transforming growth factor-α which is overexpressed by a number of human tumours. This article principally reviews previous investigations of the role of the epidermal growth factor receptor in bladder cancer and examines methods of detection, the correlation between EGFr status and known prognostic indicators and the value of assessing EGFr status in predicting clinical outcome in patients with bladder cancer. Recent studies of the c-erbB-2 proto-oncogenc in bladder cancer and of cell cycling using Ki-67 arc included.
| Original language | English |
|---|---|
| Pages (from-to) | 365-371 |
| Number of pages | 7 |
| Journal | Urologia Internationalis |
| Volume | 48 |
| Issue number | 4 |
| DOIs | |
| State | Published - 1992 |
| Externally published | Yes |
Keywords
- Bladder
- C-erbB-2
- Cancer
- Epidermal growth factor
- Prognosis
- Receptor