Discovering relations between indirectly connected biomedical concepts

Dirk Weissenborn, Michael Schroeder, George Tsatsaronis

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

Abstract

The complexity and scale of the knowledge in the biomedical domain has motivated research work towards mining heterogeneous data from structured and unstructured knowledge bases. Towards this direction, it is necessary to combine facts in order to formulate hypotheses or draw conclusions about the domain concepts. In this work we attempt to address this problem by using indirect knowledge connecting two concepts in a graph to identify hidden relations between them. The graph represents concepts as vertices and relations as edges, stemming from structured (ontologies) and unstructured (text) data. In this graph we attempt to mine path patterns which potentially characterize a biomedical relation. For our experimental evaluation we focus on two frequent relations, namely "has target", and "may treat". Our results suggest that relation discovery using indirect knowledge is possible, with an AUC that can reach up to 0.8. Finally, analysis of the results indicates that the models can successfully learn expressive path patterns for the examined relations.

Original languageEnglish
Title of host publicationData Integration in the Life Sciences - 10th International Conference, DILS 2014, Proceedings
PublisherSpringer Verlag
Pages112-119
Number of pages8
ISBN (Print)9783319085890
DOIs
StatePublished - 2014
Externally publishedYes
Event10th International Conference on Data Integration in the Life Sciences, DILS 2014 - Lisbon, Portugal
Duration: Jul 17 2014Jul 18 2014

Publication series

NameLecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics)
Volume8574 LNBI
ISSN (Print)0302-9743
ISSN (Electronic)1611-3349

Conference

Conference10th International Conference on Data Integration in the Life Sciences, DILS 2014
Country/TerritoryPortugal
CityLisbon
Period07/17/1407/18/14

Keywords

  • Biomedical Concepts
  • Relation Discovery
  • Text Mining

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