Comparison between artificial neural networks and urologists' assessment of outcome in bladder cancer - Part I: Progression and recurrence in Ta/T1 tumours

R. N.G. Naguib, K. N. Qureshi, F. C. Hamdy, D. E. Neal, J. K. Mellon

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

1 Scopus citations

Abstract

The early accurate determination of course of disease in Ta/T1 bladder cancers is an important issue in patient management and improvement of clinical outcome. For this purpose a comprehensive database of patients with newly diagnosed bladder cancer was retrospectively analyzed by artificial neural networks (ANNs) as follows. First, stage progression in 105 patients with Ta/T1 tumours was analyzed using 7 different factors including clinicopathological and molecular markers of mixed prognostic significance. Eight additional factors were then employed to analyze tumour recurrence within 6 months in 56 patients. The prediction accuracies of the ANNs were subsequently compared to those of 4 expert urologists and proved to be significantly higher in predicting stage progression. An important result of the analysis concerned the T1G3 group of tumours which is non-infiltrative at diagnosis, but has the greatest propensity to progress to muscle-invasive disease. In this group, again, the performance of the ANN exceeded that of the urologists.

Original languageEnglish
Title of host publicationAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
PublisherIEEE
Pages1233
Number of pages1
ISBN (Print)0780356756
StatePublished - 1999
Externally publishedYes
EventProceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS) - Atlanta, GA, USA
Duration: Oct 13 1999Oct 16 1999

Publication series

NameAnnual International Conference of the IEEE Engineering in Medicine and Biology - Proceedings
Volume2
ISSN (Print)0589-1019

Conference

ConferenceProceedings of the 1999 IEEE Engineering in Medicine and Biology 21st Annual Conference and the 1999 Fall Meeting of the Biomedical Engineering Society (1st Joint BMES / EMBS)
CityAtlanta, GA, USA
Period10/13/9910/16/99

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