Are diet-prostate cancer associations mediated by the IGF axis? A cross-sectional analysis of diet, IGF-1 and IGFBP-3 in healthy middle-aged men

D. Gunnell; S. E. Oliver; T. J. Peters; J. L. Donovan; R. Persad; M. Maynard; D. Gillatt; A. Pearce; F. C. Hamdy; D. E. Neal; J. M.P. Holly

doi:10.1038/sj.bjc.6600946

Are diet-prostate cancer associations mediated by the IGF axis? A cross-sectional analysis of diet, IGF-1 and IGFBP-3 in healthy middle-aged men

D. Gunnell
, S. E. Oliver
, T. J. Peters
, J. L. Donovan
, R. Persad
, M. Maynard
, D. Gillatt
, A. Pearce
, F. C. Hamdy
, D. E. Neal
, J. M.P. Holly

Research output: Contribution to journal › Article › peer-review

120 Scopus citations

Abstract

We examined the association of diet with insulin-like growth factors (IGF) in 344 disease-free men. Raised levels of IGF-1 and/or its molar ratio with IGFBP-3 were associated with higher intakes of milk, dairy products, calcium, carbohydrate and polyunsaturated fat; lower levels with high vegetable consumption, particularly tomatoes. These patterns support the possibility that IGFs may mediate some diet-cancer associations.

Original language	English
Pages (from-to)	1682-1686
Number of pages	5
Journal	British Journal of Cancer
Volume	88
Issue number	11
DOIs	https://doi.org/10.1038/sj.bjc.6600946
State	Published - Jun 2 2003
Externally published	Yes

Keywords

Diet
Epidemiology
IGF-1
IGFBP-3
Prostate cancer

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10.1038/sj.bjc.6600946

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Gunnell, D., Oliver, S. E., Peters, T. J., Donovan, J. L., Persad, R., Maynard, M., Gillatt, D., Pearce, A., Hamdy, F. C., Neal, D. E., & Holly, J. M. P. (2003). Are diet-prostate cancer associations mediated by the IGF axis? A cross-sectional analysis of diet, IGF-1 and IGFBP-3 in healthy middle-aged men. British Journal of Cancer, 88(11), 1682-1686. https://doi.org/10.1038/sj.bjc.6600946

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title = "Are diet-prostate cancer associations mediated by the IGF axis? A cross-sectional analysis of diet, IGF-1 and IGFBP-3 in healthy middle-aged men",

abstract = "We examined the association of diet with insulin-like growth factors (IGF) in 344 disease-free men. Raised levels of IGF-1 and/or its molar ratio with IGFBP-3 were associated with higher intakes of milk, dairy products, calcium, carbohydrate and polyunsaturated fat; lower levels with high vegetable consumption, particularly tomatoes. These patterns support the possibility that IGFs may mediate some diet-cancer associations.",

keywords = "Diet, Epidemiology, IGF-1, IGFBP-3, Prostate cancer",

author = "D. Gunnell and Oliver, \{S. E.\} and Peters, \{T. J.\} and Donovan, \{J. L.\} and R. Persad and M. Maynard and D. Gillatt and A. Pearce and Hamdy, \{F. C.\} and Neal, \{D. E.\} and Holly, \{J. M.P.\}",

year = "2003",

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doi = "10.1038/sj.bjc.6600946",

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Gunnell, D, Oliver, SE, Peters, TJ, Donovan, JL, Persad, R, Maynard, M, Gillatt, D, Pearce, A, Hamdy, FC, Neal, DE & Holly, JMP 2003, 'Are diet-prostate cancer associations mediated by the IGF axis? A cross-sectional analysis of diet, IGF-1 and IGFBP-3 in healthy middle-aged men', British Journal of Cancer, vol. 88, no. 11, pp. 1682-1686. https://doi.org/10.1038/sj.bjc.6600946

TY - JOUR

T1 - Are diet-prostate cancer associations mediated by the IGF axis? A cross-sectional analysis of diet, IGF-1 and IGFBP-3 in healthy middle-aged men

AU - Gunnell, D.

AU - Oliver, S. E.

AU - Peters, T. J.

AU - Donovan, J. L.

AU - Persad, R.

AU - Maynard, M.

AU - Gillatt, D.

AU - Pearce, A.

AU - Hamdy, F. C.

AU - Neal, D. E.

AU - Holly, J. M.P.

PY - 2003/6/2

Y1 - 2003/6/2

N2 - We examined the association of diet with insulin-like growth factors (IGF) in 344 disease-free men. Raised levels of IGF-1 and/or its molar ratio with IGFBP-3 were associated with higher intakes of milk, dairy products, calcium, carbohydrate and polyunsaturated fat; lower levels with high vegetable consumption, particularly tomatoes. These patterns support the possibility that IGFs may mediate some diet-cancer associations.

AB - We examined the association of diet with insulin-like growth factors (IGF) in 344 disease-free men. Raised levels of IGF-1 and/or its molar ratio with IGFBP-3 were associated with higher intakes of milk, dairy products, calcium, carbohydrate and polyunsaturated fat; lower levels with high vegetable consumption, particularly tomatoes. These patterns support the possibility that IGFs may mediate some diet-cancer associations.

KW - Diet

KW - Epidemiology

KW - IGF-1

KW - IGFBP-3

KW - Prostate cancer

UR - https://www.scopus.com/pages/publications/0037929412

U2 - 10.1038/sj.bjc.6600946

DO - 10.1038/sj.bjc.6600946

M3 - Artículo

C2 - 12771980

AN - SCOPUS:0037929412

SN - 0007-0920

VL - 88

SP - 1682

EP - 1686

JO - British Journal of Cancer

JF - British Journal of Cancer

IS - 11

ER -

Are diet-prostate cancer associations mediated by the IGF axis? A cross-sectional analysis of diet, IGF-1 and IGFBP-3 in healthy middle-aged men

Abstract

Keywords

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