Pathway Studio Collaboration with Personalised Hematology-Oncology at Wake Forest

Pathway Studio obtains biopsies placed in RNA-later on stage IV cancers, create a blueprint of their tumor (genechip or gene expression profile) or transcriptomics profile, identify dominant signal transduction pathways utilized by their individual tumor, then select molecular targeted drugs to block proliferation pathways and force the cancer cells into an apoptotic pathway. This approach may cure some patients, in other patients it decreases toxicity allowing better quality of life and improving overall survival compared to cytotoxic chemotherapy regimens. In terms of immune therapies like checkpoint inhibitors, often times many stage IV cancers do not respond, and it is clear from their gene expression profile, that their immune system has been inactivated by their tumor!